The impact of 3D cell culture on liver metabolism modeling in vitro and to Become familiar with data-driven estimations of liver injury potential in response to xenobiotic exposures using high throughput transcriptomics. (2019)

Dr. Meritxell Huch discusses how adult liver organoids can be used to understand disease mechanisms and regeneration. (2020)

Dr. Takanori Takebe discusses how organoids can be used to expand clinical applications of diseases and disorders. He shows also the modeling of hepato-biliary-pancreatic organogenesis. (2020)

This webinar discusses the differences between 2D and 3D cell culture models such as spheroid and organoid to help researchers select a suitable method and model for their research. (2020)

In the model of Dr. Takebe, multi-cellular human liver organoids have been developed from 11 different healthy and diseased PSC lines that display essential features of steatohepatitis. (2019)

Presents the development and validation of engineered human liver co-cultures for drug development applications. (2020)

Discussion about the current landscape of the prediction of drug-induced liver injury in silico and the potential advancement using deep learning methodologies.
(2020)

In silico models play an important role in reducing the number of animals used in toxicology experiments and risk assessment. (2020)

First, Dr. Ferguson compares human liver, 2D HepRG and 3D HepaRG from their metabolic activity of different enzymes. Second, Dr. Caron shows his 3D liver cellular model and its applications such as clearance. Third, Dr. Tagle talkes about liver on a chip for drug safety and efficacy assessment. (2019)

At min. 32.04 one organoid example comes from the liver, grown from liver biopsy. The liver can be grown from a stem cell to form a whole liver just in the number of cells during 3-4 months. To promote the differentiation, the medium conditions should be changed. (2019)

Dr. Huch talkes about organoid culture and applications, focusing on gastric, hepatic, pancreatic and intestinal organoids. An organoid is a mini-organ derived from tissue-specific stem cells, progenitor cells or human pluripotent stem cells. (2015)

Using 3D models such as organoid and spheroid systems in understanding disease etiology and innovating new treatment options. (2019)

Dr. David Hay talkes about the generation of endoderm from human pluripotent stem cells and differentiation into metabolically active hepatocytes. (2015)

The extracorporeal liver support-HV-TPE is the only support method to date, which has shown improved survival. Accordingly, some extracorporeal technology may have benefts when it is implemented early. (2017)

This webinar is about prediction of certain toxicity endpoints such as cholestasis, as well as deep learning approaches to overcome insufficient size and imbalance of toxicity datasets. (2020)

Dr Patlewicz (US EPA) and Professor Cronin talk about the QSARs and its use to meet regulatory testing requirements under REACH. (2018)